The Pearl Jam frontman is doing a series of public service announcements to raise research funds for epidermolysis bullosa [pr: epp-i-derm-oh-LIE-sis bull-OH-sa], an ailment that causes blisters and painful patches to appear on the skin and internal organs. Vedder says, “When I first heard about it, it was quite hard to grasp the intensity of the condition. It’s about the most insane skin disorder you can imagine. And when you realize it also affects the internal organs, then you see it as diabolical. It’s very hard to describe until you meet the young folks with it. And they make you realize how much you take for granted. You also realize these are some of the strongest, coolest, most admirable people on the face of the earth. “

The EB Foundation hopes to raise $5 million in its quest for a cure.